Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

1.0K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.0K
Antisocial Personality Disorder01:24

Antisocial Personality Disorder

818
Antisocial personality disorder is a chronic mental health condition characterized by persistent patterns of disregard for the rights and well-being of others. Individuals with antisocial personality disorder exhibit behaviors that include deceitfulness, impulsivity, irresponsibility, aggression, and a profound lack of empathy. These traits often manifest early in life and persist into adulthood, leading to significant personal, social, and legal consequences.
Behavioral Characteristics and...
818
Borderline Personality Disorder01:25

Borderline Personality Disorder

663
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
663
Self-Report Tests of Personality01:22

Self-Report Tests of Personality

888
Self-report inventories are objective personality assessments that use multiple-choice items or numbered scales, typically ranging from 1 (strongly disagree) to 5 (strongly agree). They are often called Likert scales after Rensis Likert. These inventories are widely used due to their ease of administration and cost-effectiveness. One of the most prominent examples is the Minnesota Multiphasic Personality Inventory (MMPI), initially developed in the 1940s to assess abnormal personality traits.
888
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

706
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
706
Personality Disorders: Schizotypal and Histrionic01:20

Personality Disorders: Schizotypal and Histrionic

626
Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...
626

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing Affective Cognitive Control in Bipolar Disorder Using Transcranial Alternating Current Stimulation: A Double-Blind, Randomized, Sham-Controlled Clinical Trial and Proof of Concept Study.

Bipolar disorders·2026
Same author

ORIGIN-1 trial: study protocol for an organoid-guided N-of-1 trial evaluating CFTR modulator response in cystic fibrosis with rare non-F508del mutations.

Trials·2026
Same author

AK8 deficiency causes primary ciliary dyskinesia by disrupting energy homeostasis in the airways.

American journal of respiratory and critical care medicine·2026
Same author

Predicting suicidal ideation from depression screening data: A network-augmented machine learning approach.

Journal of affective disorders·2026
Same author

Understanding Otitis Media Among Aboriginal Children in the Kimberley Region of Western Australia: An Opportunity to Improve Health Outcomes.

Journal of paediatrics and child health·2026
Same author

Using National COVID cohort collaborative (N3C) data to explore impact of COVID-19 infection on kidney function in patients receiving lithium therapy.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Latent subdimensions of anxiety and depression differentially influence exertion of effort in pursuit of reward versus avoidance of threat.

Translational psychiatry·2026
Same journal

The cell-type specific interaction based drug repurposing for psychiatric disorders.

Translational psychiatry·2026
Same journal

Psychotropic drug-induced weight gain and untargeted metabolomics: machine learning-driven results from a prospective cohort study.

Translational psychiatry·2026
Same journal

The effects of propranolol and corticosterone on susceptibility priming in a mouse model of social defeat stress.

Translational psychiatry·2026
Same journal

The physiological foundation of extinction improvement by tDCS over the ventromedial prefrontal cortex (vmPFC) in healthy humans: an fMRI study.

Translational psychiatry·2026
Same journal

Multi-ancestry multi-trait analysis reveals shared genetics across major psychiatric disorders and Alzheimer's disease.

Translational psychiatry·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.4K

Testing frameworks for personalizing bipolar disorder.

Amy L Cochran1, André Schultz2, Melvin G McInnis3

  • 1Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, 53705, USA.

Translational Psychiatry
|February 3, 2018
PubMed
Summary
This summary is machine-generated.

Mathematical modeling reveals bipolar disorder may stem from affective instability, not rhythmic mood cycles or distinct states. This finding offers personalized treatment potential for mood disorders.

More Related Videos

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

13.2K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.5K

Related Experiment Videos

Last Updated: Feb 15, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.4K
Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

13.2K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.5K

Area of Science:

  • Psychiatry
  • Computational Neuroscience
  • Mathematical Biology

Background:

  • Bipolar disorder is characterized by recurrent manic and depressive episodes.
  • Mathematical modeling offers potential for personalized diagnosis and prediction in bipolar disorder.
  • Existing models propose rhythmic processes, multiple stable states, or anti-correlated symptoms.

Purpose of the Study:

  • To test competing mathematical hypotheses of bipolar disorder.
  • To analyze prospective mood symptom data from bipolar patients.
  • To identify the underlying mechanism of mood fluctuations in bipolar disorder.

Main Methods:

  • Prospective cohort study of 178 bipolar patients over 4+ years.
  • Utilized self-report assessments for mania and depression symptoms.
  • Statistical analysis to evaluate proposed modeling frameworks.

Main Results:

  • Data did not support rhythmic process or multiple stable state models.
  • Evidence against significant anti-correlation between manic and depressive symptoms.
  • Findings suggest bipolar disorder may arise from impaired mood regulation (affective instability).

Conclusions:

  • Bipolar disorder may be better explained by affective instability rather than cyclical or state-based models.
  • An affective instability model can be personalized for individual patient courses.
  • This approach may benefit chronic disorders with affective components.