Related Experiment Video
Updated: Feb 15, 2026
06:02
Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens
Published on: January 31, 2016
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Myofibroblasts: Master of disguise
Bhavana S Bagalad1, K P Mohan Kumar2, H K Puneeth1
1Department of Oral and Maxillofacial Pathology, St. Joseph Dental College, Eluru, Andhra Pradesh, India.
Journal of Oral and Maxillofacial Pathology : JOMFP
|February 3, 2018
Summary
Myofibroblasts, smooth muscle-like fibroblasts, are crucial in tissue repair and disease. This review details their roles in organogenesis, regeneration, inflammation, and cancer development.
Area of Science:
- Cell Biology
- Histology
- Pathology
Background:
- Myofibroblasts are specialized fibroblasts with smooth muscle characteristics.
- They play a dual role in both physiological and pathological processes.
- These cells are involved in extracellular matrix dynamics.
Purpose of the Study:
- To review the diverse functions of myofibroblasts.
- To elucidate the role of myofibroblasts in various biological processes.
- To discuss myofibroblastic lesions and their implications.
Main Methods:
- Literature review of myofibroblast research.
- Synthesis of information on myofibroblast functions.
- Analysis of myofibroblast involvement in disease.
Main Results:
- Myofibroblasts are central to organogenesis and tissue repair.
- They significantly contribute to inflammatory responses.
- Myofibroblasts are implicated in the progression of tumorigenesis.
Conclusions:
- Myofibroblasts are key players in tissue homeostasis and disease.
- Understanding myofibroblast biology is vital for therapeutic strategies.
- Further research into myofibroblastic lesions is warranted.
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