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Related Concept Videos

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Cancer stem cells: An insight.

Rohit Balwant Moharil1, Alka Dive1, Shubhangi Khandekar1

  • 1Department of Oral Pathology, VSPM DCRC, Nagpur, Maharashtra, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|February 3, 2018
PubMed
Summary

Cancer stem cells (CSCs) possess self-renewal capabilities and drive cancer development, metastasis, and recurrence. Understanding CSCs is crucial for effective cancer therapy and overcoming treatment resistance.

Keywords:
Cancer stem cellscancer stem cell markershead and neck squamous cell carcinomametastasisstem cell niche

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Area of Science:

  • Oncology
  • Cell Biology

Background:

  • Cancer stem cells (CSCs) are a subpopulation of cells within tumors responsible for tumor initiation, growth, and metastasis.
  • CSCs are found in various cancers, including breast, brain, lung, and colon cancer.
  • The precise origin of CSCs remains an active area of research.

Purpose of the Study:

  • To review the fundamental characteristics of cancer stem cells.
  • To discuss the proposed origins of CSCs.
  • To explore the implications of CSCs in cancer therapy and drug resistance.

Main Methods:

  • Literature review of studies on cancer stem cells.
  • Analysis of proposed hypotheses regarding CSC origin.
  • Examination of CSC roles in cancer progression and treatment.

Main Results:

  • CSCs exhibit self-renewal and multi-differentiation potential.
  • CSCs are implicated in tumor evolution, metastasis, and recurrence.
  • CSCs contribute significantly to therapeutic resistance.

Conclusions:

  • CSCs are key drivers of cancer and therapeutic challenges.
  • Further research into CSC origins and targeting is essential for improving cancer treatment outcomes.