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Related Experiment Video

Updated: Feb 15, 2026

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
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Primary progressive aphasia: a clinical approach.

Charles R Marshall1, Chris J D Hardy2, Anna Volkmer3

  • 1Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK. charles.marshall@ucl.ac.uk.

Journal of Neurology
|February 3, 2018
PubMed
Summary

Primary progressive aphasias (PPAs) are language-led dementias. This clinical approach aids non-specialists in diagnosing and managing PPA syndromes by outlining assessment frameworks and diagnostic roadmaps.

Keywords:
Alzheimer’s diseaseFrontotemporal dementiaLogopenic aphasiaPrimary progressive aphasiaSemantic dementia

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Area of Science:

  • Neurology
  • Neuroscience
  • Linguistics

Background:

  • Primary progressive aphasias (PPAs) represent a complex group of neurodegenerative disorders.
  • These 'language-led' dementias present significant diagnostic and management challenges.

Purpose of the Study:

  • To present a practical clinical approach to progressive aphasias for non-specialists.
  • To provide a framework for language assessment and diagnostic roadmapping for common PPA syndromes.

Main Methods:

  • Review of clinical experience with PPA syndromes.
  • Outline of a tailored language assessment framework.
  • Description of defining features, diagnostic pearls, and neuroanatomical associations for canonical PPA syndromes (nonfluent, semantic, logopenic).

Main Results:

  • Identification of key diagnostic features and potential pitfalls for PPA syndromes.
  • Proposal of a structured diagnostic roadmap for progressive aphasias.
  • Discussion of management principles and future research directions.

Conclusions:

  • A systematic clinical approach can improve the diagnosis and management of primary progressive aphasias.
  • Understanding specific PPA syndrome features and employing a diagnostic roadmap are crucial.
  • Future progress may involve addressing information processing deficits and utilizing novel biomarkers.