Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced-fit Model01:13

Induced-fit Model

89.7K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
89.7K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.2K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.2K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.6K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.6K
Induced Electric Dipoles01:28

Induced Electric Dipoles

4.9K
A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...
4.9K
Induced Electric Fields01:23

Induced Electric Fields

4.7K
The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
4.7K
Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

2.4K
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scalp cooling outcomes in patients receiving trastuzumab deruxtecan for metastatic breast cancer.

ESMO open·2026
Same author

Vascular Destabilization and Pericyte Detachment are Mediated by hIAPP Aggregation in Transgenic Mice.

bioRxiv : the preprint server for biology·2026
Same author

Outcomes of patients with relapsed/refractory lymphoplasmacytic lymphoma/waldenström macroglobulinemia treated with venetoclax: a multicenter retrospective analysis.

Blood cancer journal·2025
Same author

ERK1/2 pro-survival signalling is suppressed by pirtobrutinib in ibrutinib-resistant MYD88-mutated lymphoma cells.

British journal of haematology·2024
Same author

Report of consensus panel 2 from the 11th international workshop on Waldenström's macroglobulinemia on the management of relapsed or refractory WM patients.

Seminars in hematology·2023
Same author

Report of consensus panel 7 from the 11th international workshop on Waldenström macroglobulinemia on priorities for novel clinical trials.

Seminars in hematology·2023

Related Experiment Video

Updated: Feb 15, 2026

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
11:35

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

17.0K

Ixazomib-induced cutaneous necrotizing vasculitis.

A Alloo1, H Khosravi2, S R Granter3

  • 1Department of Dermatology, Northwell Health, Hofstra Northwell School of Medicine, Hempstead, NY, USA.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|February 3, 2018
PubMed
Summary

Ixazomib, a multiple myeloma drug, can cause skin issues like necrotizing vasculitis. Early detection and dose adjustment can manage these side effects, improving patient quality of life.

Keywords:
Cutaneous toxicityIxazomibProteasome inhibitorRashVasculitis

More Related Videos

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

8.2K
Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

20.4K

Related Experiment Videos

Last Updated: Feb 15, 2026

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
11:35

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

17.0K
A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

8.2K
Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

20.4K

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Ixazomib is a proteasome inhibitor used for multiple myeloma and Waldenstrom's macroglobulinemia.
  • Cutaneous adverse events are known with proteasome inhibitors, but ixazomib's specific side effect profile requires further documentation.

Observation:

  • Two patients, one with multiple myeloma and one with Waldenstrom's macroglobulinemia, developed cutaneous necrotizing vasculitis.
  • Neither patient showed signs of systemic vasculitis.

Findings:

  • Ixazomib treatment led to cutaneous necrotizing vasculitis in both patients.
  • Dose reduction of ixazomib and low-dose prednisone resolved the skin eruptions.
  • Patients completed their anti-cancer regimens after intervention.

Implications:

  • Characterizing ixazomib-induced cutaneous toxicities aids early intervention and treatment adherence.
  • Understanding these side effects improves patient quality of life and informs clinical management.
  • This case series highlights the importance of monitoring for and managing dermatologic toxicities of novel cancer therapies.