Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Feedback Inhibition00:46

Feedback Inhibition

57.4K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.4K
Cognitive Dissonance01:38

Cognitive Dissonance

37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
Enzyme Inhibition01:30

Enzyme Inhibition

92.9K
Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
92.9K
Language and Cognition01:27

Language and Cognition

820
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
820
Cognitive Therapy01:25

Cognitive Therapy

1.3K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.3K
Cognition and Behavior01:23

Cognition and Behavior

386
Social psychology examines the complex interplay between individual mental processes and social interactions. Historically, the field was divided into two domains: social behavior and social cognition. Researchers focusing on social behavior analyzed actions within social contexts, such as conformity, aggression, or cooperation. Meanwhile, social cognition researchers investigated how people perceive, interpret, and mentally represent their social environments. However, modern perspectives no...
386

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of artificial diet on glycolytic pathway and immune response in mandarin fish (Siniperca chuatsi).

Fish & shellfish immunology·2026
Same author

Effects of faba beans (<i>Vicia faba L.</i>) on muscle texture and fibrosis biomarkers of Nile tilapia (<i>Oreochromis niloticus</i>).

Food chemistry. Molecular sciences·2025
Same author

Systemic immune activity occurs during human immune system maturation.

Cell·2025
Same author

Expression analysis of the irak1 gene in Siniperca chuatsi against Aeromonas hydrophila and SNP development.

Fish & shellfish immunology·2025
Same author

Hepcidin defense patterns in intestine of mandarin fish (Siniperca chuatsi) against Aeromonas hydrophila infection.

Fish & shellfish immunology·2024
Same author

Autoimmune astrocytopathy double negative for AQP4-IgG and GFAP-IgG: Retrospective research of clinical practice, biomarkers, and pathology.

CNS neuroscience & therapeutics·2024

Related Experiment Video

Updated: Feb 15, 2026

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research
03:26

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

1.9K

Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation.

Zhao-Hui Yao1, Xiao-Li Yao2, Yong Zhang3

  • 1Department of Geriatrics, Renmin Hospital of Wuhan University, #238 Jiefang Road, Wuhan, 430060, China. yaozhaohui2004@126.com.

Neurochemical Research
|February 3, 2018
PubMed
Summary

Luteolin, a natural flavonoid, protects against cognitive decline caused by chronic cerebral hypoperfusion (CCH). It reduces neuroinflammation and oxidative stress, improving memory and synaptic plasticity in rats.

Keywords:
Chronic cerebral hypoperfusionCognition dysfunctionLuteolinNeuroinflammation

More Related Videos

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

17.1K
Author Spotlight: Exploring the Potential of Massage Therapy in Cerebral Palsy Using Animal Models
08:24

Author Spotlight: Exploring the Potential of Massage Therapy in Cerebral Palsy Using Animal Models

Published on: August 11, 2023

2.7K

Related Experiment Videos

Last Updated: Feb 15, 2026

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research
03:26

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

1.9K
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

17.1K
Author Spotlight: Exploring the Potential of Massage Therapy in Cerebral Palsy Using Animal Models
08:24

Author Spotlight: Exploring the Potential of Massage Therapy in Cerebral Palsy Using Animal Models

Published on: August 11, 2023

2.7K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Chronic cerebral hypoperfusion (CCH) is linked to neuroinflammation and oxidative stress, contributing to cognitive deficits.
  • Luteolin, a plant-derived flavonoid, exhibits diverse pharmacological properties, including anti-inflammatory and antioxidant effects.

Purpose of the Study:

  • To investigate luteolin's potential to prevent CCH-induced cognitive dysfunction.
  • To examine the anti-inflammatory and antioxidant mechanisms underlying luteolin's effects.

Main Methods:

  • Utilized a bilateral common carotid arteries ligation (2VO) rat model to induce CCH.
  • Employed enzyme-linked immunosorbent assays, enzyme activity assays, behavioral tests, immunohistochemistry, and electrophysiology.
  • Assessed neuroinflammation markers (TNF-α, IL-1β, IL-6), oxidative stress markers (MDA, SOD, GPx), microglia/astrocyte activation, cognitive function, and long-term potentiation (LTP).

Main Results:

  • CCH increased neuroinflammation and oxidative stress markers while impairing cognitive function and LTP.
  • Luteolin treatment reversed these CCH-induced changes, reducing inflammatory markers and oxidative stress.
  • Luteolin inhibited microglia and astrocyte activation, ameliorated cognitive deficits, and restored LTP.

Conclusions:

  • Luteolin demonstrates neuroprotective effects against CCH-induced cognitive impairment.
  • Its anti-inflammatory and antioxidant properties make it a promising therapeutic agent for CCH-related cognitive dysfunction.
  • Luteolin may also be beneficial for other brain diseases associated with inflammation.