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Cortex-, Hippocampus-, Thalamus-, Hypothalamus-, Lateral Septal Nucleus- and Striatum-specific In Utero Electroporation in the C57BL/6 Mouse
Published on: January 18, 2016
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Characteristics of Isolated Ventricular Septal Defects Less Likely to Close In Utero
Ann C Chau1, Andrew Jones2, Monique Sutherland2
1Division of Maternal-Fetal Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Summary
Fetal ventricular septal defects (VSDs) with other cardiac defects or abnormal karyotypes are less likely to close before birth. Smaller VSDs, 2mm or less, consistently closed prenatally.
Area of Science:
- Cardiology
- Prenatal Diagnosis
- Genetics
Background:
- Fetal ventricular septal defects (VSDs) are common congenital heart abnormalities.
- Understanding factors influencing prenatal closure is crucial for management.
Purpose of the Study:
- To identify characteristics of fetal VSDs associated with a lower likelihood of prenatal closure.
- To inform prognostic assessments and clinical decision-making.
Main Methods:
- Retrospective cohort study of 148 fetuses diagnosed with VSD.
- Monthly follow-up with prenatal echocardiography and postnatal confirmation.
- Statistical analysis including logistic regression to assess predictors of closure.
Main Results:
- 84% of VSDs closed prenatally.
- Persistent VSDs were associated with other cardiac defects (P<.001) and abnormal karyotypes (P<.001).
- Larger initial and maximal prenatal VSD sizes were observed in persistent cases. VSDs ≤2mm closed prenatally.
Conclusions:
- Complex cardiac defects and abnormal karyotypes significantly reduce the probability of prenatal VSD closure.
- These factors are critical indicators for predicting VSD persistence.
Keywords:
echocardiographyfetal ventricular septal defectsmembranousmuscularobstetric (detailed fetal anatomy)obstetric (third trimester)ventricular septal defects with a fixed sizeventricular septal defects with an increasing sizeMore Related Videos
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