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Published on: September 8, 2021
KCa(H2 O)2 [FeIII (CN)6 ]⋅H2 O Nanoparticles as an Antimicrobial Agent against Staphylococcus aureus
Zhongxia Wang1, Bing Yu2, Huda Alamri1
1Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44240, USA.
Abstract:
Biocompatible nanoparticles based on a calcium analogue of Prussian blue were designed and synthesized to take advantage of their ability to penetrate the cell membrane in Staphylococcus aureus and to undergo selective ion exchange with intracellular iron to disrupt iron metabolism in such pathogenic bacteria for antibacterial applications. KCa(H2 O)2 [FeIII (CN)6 ]⋅H2 O nanoparticles penetrate the bacterial cell membrane and sequester intracellular iron by ion exchange to form insoluble Prussian blue, thus inhibiting bacterial growth.
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