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Updated: Feb 15, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
[Can we not do without oxygen administration through a nasal cannula?]
Y M Smulders1, J G van den Aardweg
1VUmc, afd. Interne Geneeskunde, Amsterdam.
Abstract:
Nasal cannulae for oxygen administration are applied abundantly in clinical medicine, even though their use may cause patient discomfort. Although nasal cannulae may be effective in increasing oxygen uptake to some degree, they are unlikely to prevent severe hypoxaemia. Furthermore, they are often used when arterial oxygen saturation is already ≥ 90%, in which case additional oxygenation is usually not required, nor does it relieve the sensation of dyspnoea.
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