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Clinical Outcomes of Myocardial Bridging versus No Myocardial Bridging in Patients with Apical Hypertrophic

Shan-Shan Zhai, Chao-Mei Fan, Shuo-Yan An

    Cardiology
    |February 3, 2018
    PubMed

    Insights

    Myocardial bridging (MB) is more common in apical hypertrophic cardiomyopathy (AHCM) patients, leading to worse symptoms and increased cardiovascular event risk, though not higher mortality.

    Area of Science:

    • Cardiology
    • Cardiovascular Research
    • Medical Imaging

    Background:

    • Apical hypertrophic cardiomyopathy (AHCM) is a distinct form of hypertrophic cardiomyopathy.
    • Myocardial bridging (MB) involves the compression of a coronary artery segment during systole.
    • The clinical significance of MB in AHCM remains incompletely understood.

    Purpose of the Study:

    • To investigate the prevalence of myocardial bridging in patients diagnosed with apical hypertrophic cardiomyopathy.
    • To evaluate the clinical effects and cardiovascular outcomes associated with myocardial bridging in this patient cohort.

    Main Methods:

    • Retrospective analysis of angiograms from 212 AHCM patients to identify myocardial bridging.
    • Classification of patients into two groups: AHCM with MB and AHCM without MB.
    • Review of cardiovascular risk factors, symptoms, cardiovascular events, and mortality.

    Main Results:

    • Myocardial bridging was identified in 60 of the 212 AHCM patients.
    • Patients with MB exhibited significantly higher rates of angina, myocardial infarction-like presentations, and severe angina.
    • Cardiovascular event-free survival was significantly lower in AHCM patients with MB compared to those without.

    Conclusions:

    • Myocardial bridging is associated with more severe symptoms and an increased risk of cardiovascular events in AHCM patients.
    • While cardiovascular mortality was similar between groups, MB is an independent risk factor for cardiovascular events in AHCM.
    Abstract

    Keywords:
    Apical hypertrophic cardiomyopathyCardiovascular eventsCardiovascular mortalityLate gadolinium enhancementMyocardial bridging

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