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Updated: Feb 15, 2026

Electroporation of Craniofacial Mesenchyme
Published on: November 28, 2011
[Biodegradable fixation systems in pediatric craniofacial surgery: 10-year experience with 324 patients]
S A Yasonov1, A V Lopatin2, V A Bel'chenko3
1Russian Children's Clinical Hospital, Moscow, Russia, 119571, Pirogov Russian National Research Medical University, Moscow, Russia, 117997.
Biodegradable osteosynthesis systems offer advantages over traditional metal constructs, particularly for pediatric craniofacial surgery. Ultrasonic welding enhances fixation rigidity for resorbable materials, aiding bone healing.
Area of Science:
- Orthopedic surgery
- Biomaterials science
- Pediatric reconstructive surgery
Background:
- Resorbable materials offer advantages in osteosynthesis, including biocompatibility and gradual resorption, promoting bone healing.
- High cost limits widespread use of resorbable systems, despite their benefits for pediatric patients during growth.
- Biodegradable systems provide fixation rigidity comparable to metal constructs with reduced infection risk.
Purpose of the Study:
- To compare the clinical advantages and disadvantages of traditional (plate/screw) and ultrasonic welding biodegradable fixation systems.
- To evaluate the efficacy of resorbable osteosynthesis in pediatric craniofacial reconstructive surgery.
Main Methods:
- A retrospective analysis of 324 pediatric patients undergoing craniofacial reconstructive surgery over 10 years.
- Comparison of outcomes between 244 patients treated with traditional plate/screw biodegradable systems and 80 patients treated with ultrasonic welding biodegradable systems.
Main Results:
- Ultrasonic welding facilitates fixation of thin bones, offering necessary rigidity where screws are insufficient.
- Biodegradable systems, especially when assembled with ultrasonic welding, demonstrate potential for improved bone healing and functional recovery.
- Clinical evidence supports the use of resorbable systems in pediatric craniofacial surgery, with ultrasonic welding offering unique advantages.
Conclusions:
- Biodegradable fixation systems, particularly those utilizing ultrasonic welding, present a viable and advantageous alternative to traditional metal constructs in pediatric craniofacial surgery.
- Ultrasonic welding enhances the application and rigidity of resorbable osteosynthesis, facilitating bone healing and return to physiological function.
- Further clinical evaluation is warranted to fully elucidate the long-term benefits of ultrasonic welding in resorbable osteosynthesis for pediatric reconstructive procedures.
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Fixation and Sectioning
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
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