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[Some features controlling the blood D-dimer level after resection of malignant brain glioma]
I D Rozanov1, E I Shirikov1, A S Balkanov1
1Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia, 129110.
Abstract:
A high blood D-dimer level is often diagnosed in patients with malignant brain glioma (MBG), with 24% of these patients being detected with deep vein thrombosis of the leg and/or pulmonary embolism (PE). The cause of an elevated blood D-dimer level in most other cases remains unclear. The purpose of this study is to identify the features associated with an increased blood D-dimer level in patients after MBG resection, which may be used to improve the efficacy of adjuvant radiation therapy (ART).
Results:
The study included 50 patients. Three to four weeks after resection of malignant brain glioma (MBG), the blood D-dimer level was determined in patients immediately before the onset of ART. An increase in the blood D-dimer level more than by 0.25 μg/mL was detected in 78% of patients. More often, a high D-dimer level was detected in patients aged 60 years or more. In the same age group, an increase in the D-dimer level was significantly larger (p<0.05) than in younger patients (1.2 and 0.6 μg/mL, respectively). The degree of brain tumor malignancy did not affect the rate and value of an increase in the blood D-dimer level.
Conclusion:
Our findings indicate that an increased blood D-dimer level in patients without symptoms of venous thrombosis after craniotomy for MBG is more pronounced in patients aged 60 years and over. The degree of glioma malignancy has no significant effect on this indicator.
Insights
Elevated D-dimer levels after malignant brain glioma (MBG) surgery are common, particularly in patients over 60. Tumor grade did not impact D-dimer levels in this study.
Area of Science:
- Neuro-oncology
- Hematology
- Oncologic Surgery
Background:
- Malignant brain glioma (MBG) patients frequently exhibit elevated D-dimer levels.
- Deep vein thrombosis (DVT) and pulmonary embolism (PE) are diagnosed in 24% of MBG patients.
- The reasons for elevated D-dimer in other MBG patients remain unclear.
Purpose of the Study:
- To identify factors associated with increased blood D-dimer levels post-MBG resection.
- To potentially enhance adjuvant radiation therapy (ART) efficacy through D-dimer level insights.
Main Methods:
- Blood D-dimer levels were measured in 50 MBG patients 3-4 weeks post-resection, before ART.
- Patient age and glioma malignancy grade were analyzed in relation to D-dimer levels.
Main Results:
- 78% of patients showed elevated D-dimer (>0.25 μg/mL) before ART.
- Higher D-dimer levels were significantly more prevalent and pronounced in patients aged 60+ (1.2 μg/mL vs. 0.6 μg/mL).
- Glioma malignancy grade did not correlate with D-dimer level increase.
Conclusions:
- Post-craniotomy D-dimer elevation in MBG patients without venous thrombosis symptoms is more significant in those aged 60 and above.
- Glioma malignancy grade does not appear to influence D-dimer levels.
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