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Published on: August 25, 2023
FABP4 as a biomarker for knee osteoarthritis
Chaofan Zhang1,2, Teng Li1, Kwong Yuen Chiu1
1Department of Orthopaedics & Traumatology, The University of Hong Kong, Hong Kong SAR 999077, PR China.
Aim:
To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA).
Methods:
Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA.
Results:
Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29). FABP4 level of IPFP was positively correlated with SF FABP4.
Conclusion:
OA patients had significantly high systemic and local FABP4, and IPFP may be the main source of FABP4 in synovial cavity. FABP4 may be a promising biomarker for OA.
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