Related Experiment Video

Updated: Feb 15, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K

Apoptosis: A Target for Anticancer Therapy

Claire M Pfeffer1, Amareshwar T K Singh2

  • 1Department of Biology, Division of Natural and Social Sciences, Carthage College, Kenosha, WI 53140, USA. cpfeffer@carthage.edu.

International Journal of Molecular Sciences
|February 3, 2018
PubMed

Insights

Apoptosis, a key cell death process, is crucial for cancer therapy. Plant-derived compounds show promise by activating apoptosis, overcoming cancer

Area of Science:

  • Oncology
  • Cell Biology
  • Pharmacology

Background:

  • Apoptosis, or programmed cell death, is a critical cellular process often dysregulated in cancer.
  • Cancer cells frequently evade apoptosis through mechanisms like altered protein expression, leading to chemotherapy resistance.
  • Targeting apoptotic pathways presents a viable strategy for novel anticancer therapies.

Purpose of the Study:

  • To explore the potential of plant-derived compounds as anticancer agents.
  • To investigate the role of apoptosis activation in mediating the anticancer effects of these compounds.
  • To understand how these compounds overcome cancer's resistance to apoptosis.

Main Methods:

  • Review of scientific literature on apoptosis and plant-derived anticancer compounds.
  • Analysis of molecular mechanisms underlying apoptosis regulation in cancer.
  • Examination of how plant compounds modulate apoptotic pathways.

Main Results:

  • Plant-derived compounds demonstrate significant anticancer activity.
  • These compounds effectively activate both intrinsic and extrinsic apoptotic pathways.
  • Activation of apoptosis by plant compounds can overcome cancer cell resistance.

Conclusions:

  • Plant-derived compounds are promising candidates for developing new anticancer therapies.
  • Targeting apoptosis represents a key strategy for overcoming chemotherapy resistance in cancer.
  • Further research into these compounds could lead to novel cancer treatments.
Keywords:
anticancer therapyapoptosisapoptotic evasioncurcumin

More Related Videos

Synthesis of an In vivo MRI-detectable Apoptosis Probe06:58

Synthesis of an In vivo MRI-detectable Apoptosis Probe

Published on: July 31, 2012

9.6K
Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

4.7K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
15.3K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Group Therapy01:26

Group Therapy

Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
472
Behavior Therapy01:22

Behavior Therapy

Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
752
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
310