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Apoptosis: A Target for Anticancer Therapy.

Claire M Pfeffer1, Amareshwar T K Singh2

  • 1Department of Biology, Division of Natural and Social Sciences, Carthage College, Kenosha, WI 53140, USA. cpfeffer@carthage.edu.

International Journal of Molecular Sciences
|February 3, 2018
PubMed
Summary
This summary is machine-generated.

Apoptosis, a key cell death process, is crucial for cancer therapy. Plant-derived compounds show promise by activating apoptosis, overcoming cancer

Keywords:
anticancer therapyapoptosisapoptotic evasioncurcumin

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Area of Science:

  • Oncology
  • Cell Biology
  • Pharmacology

Background:

  • Apoptosis, or programmed cell death, is a critical cellular process often dysregulated in cancer.
  • Cancer cells frequently evade apoptosis through mechanisms like altered protein expression, leading to chemotherapy resistance.
  • Targeting apoptotic pathways presents a viable strategy for novel anticancer therapies.

Purpose of the Study:

  • To explore the potential of plant-derived compounds as anticancer agents.
  • To investigate the role of apoptosis activation in mediating the anticancer effects of these compounds.
  • To understand how these compounds overcome cancer's resistance to apoptosis.

Main Methods:

  • Review of scientific literature on apoptosis and plant-derived anticancer compounds.
  • Analysis of molecular mechanisms underlying apoptosis regulation in cancer.
  • Examination of how plant compounds modulate apoptotic pathways.

Main Results:

  • Plant-derived compounds demonstrate significant anticancer activity.
  • These compounds effectively activate both intrinsic and extrinsic apoptotic pathways.
  • Activation of apoptosis by plant compounds can overcome cancer cell resistance.

Conclusions:

  • Plant-derived compounds are promising candidates for developing new anticancer therapies.
  • Targeting apoptosis represents a key strategy for overcoming chemotherapy resistance in cancer.
  • Further research into these compounds could lead to novel cancer treatments.