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Updated: Feb 15, 2026

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RNA Secondary Structure Prediction Using High-throughput SHAPE
Published on: May 31, 2013
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Non-covalent Metallo-Drugs: Using Shape to Target DNA and RNA Junctions and Other Nucleic Acid Structures
Metal Ions in Life Sciences
|February 3, 2018
Abstract:
The most effective class of anticancer drugs in clinical use are the platins which act by binding to duplex B-DNA. Yet duplex DNA is not DNA in its active form, and many other structures are formed in cells; for example, Y-shaped fork structures are involved in DNA replication and transcription and 4-way junctions with DNA repair. In this chapter we explore how large, cationic metallo-supramolecular structures can be used to bind to these less common, yet active, nucleic acid structures.
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