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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Protein Complexes with Interchangeable Parts01:57

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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Group Therapy01:26

Group Therapy

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Updated: Feb 15, 2026

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
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Copper Complexes in Cancer Therapy.

Delphine Denoyer, Sharnel A S Clatworthy, Michael A Cater

    Metal Ions in Life Sciences
    |February 3, 2018
    PubMed
    Summary

    Copper complexes are being repurposed for cancer therapy, showing promise in preclinical and clinical studies. These compounds regulate copper levels, impacting cancer growth, angiogenesis, and metastasis with various mechanisms of action.

    Area of Science:

    • Biochemistry and Pharmacology
    • Metallodrugs
    • Cancer Therapeutics

    Background:

    • Copper homeostasis is crucial for cellular function, with dysregulation linked to diseases like Wilson's disease.
    • Copper complexes have a history of antimicrobial use and are explored for neurodegenerative diseases.
    • Copper's role in cancer progression (growth, angiogenesis, metastasis) is increasingly recognized.

    Purpose of the Study:

    • To provide a historical overview of copper complexes repurposed for cancer therapy.
    • To detail newly developed copper compounds with anticancer potential.
    • To summarize mechanisms of action, molecular targets, and clinical trial progress.

    Main Methods:

    • Review of existing literature on copper complexes in therapy.

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  • Analysis of historical and novel copper-based compounds for anticancer activity.
  • Examination of preclinical and clinical trial data.

    • Main Results:

    • Established copper complexes (e.g., tetrathiomolybdate, clioquinol) show anticancer activity.
    • Novel, tailor-made copper complexes are emerging as promising anticancer agents.
    • Clinical trials are actively evaluating the efficacy of copper complexes in cancer treatment.

    Conclusions:

    • Copper complexes represent a significant area of development in cancer therapy.
    • Understanding copper's role in cancer facilitates the design of targeted metallodrugs.
    • Ongoing research and clinical trials are advancing the therapeutic application of copper complexes.