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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
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Updated: Feb 15, 2026

Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin
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Stem cell and skin rejuvenation.

Farshad Zarei1, Abolfazl Abbaszadeh2

  • 1a Assistant of Plastic and Reconstructive Surgery , Lorestan University of Medical Sciences , Khoramabad , Iran.

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|February 3, 2018
PubMed
Summary

Stem cell therapies offer tissue repair in cosmetic surgery. Adipose-derived stem cells are preferred for their versatility and accessibility in plastic surgery applications.

Keywords:
Stem cellsbreast augmentationcosmetic surgeryfacial lipoatrophy

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Area of Science:

  • Regenerative Medicine
  • Cosmetic Surgery
  • Biotechnology

Background:

  • Stem cell therapies are increasingly utilized in cosmetic and plastic surgery for tissue regeneration.
  • Various stem cell types show potential in applications like facial lipoatrophy, skin rejuvenation, breast enhancement, and body contouring.

Purpose of the Study:

  • To review and summarize the current applications of stem cells in cosmetic and plastic surgery.

Main Methods:

  • Literature review of studies on stem cell applications in cosmetic surgery.
  • Analysis of stem cell types and their specific uses in plastic surgery procedures.

Main Results:

  • Adipose-derived stem cells are the most commonly used due to their differentiation potential (mesenchymal, ectodermal, endodermal) and ease of harvesting.
  • Stem cells are effective in diverse cosmetic procedures including facial reconstruction, skin aging reversal, and body sculpting.

Conclusions:

  • Stem cell-based treatments, particularly those using adipose-derived stem cells, are a significant advancement in cosmetic and plastic surgery.
  • Further research can expand the scope of stem cell applications for enhanced aesthetic outcomes.