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Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus

Amanda E Hernan1, J Matthew Mahoney1, Willie Curry1

  • 1Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, Vermont, United States of America.

Plos One
|February 3, 2018
PubMed
Summary

Environmental enrichment (EE) improves spatial cognition in a methylazoxymethanol (MAM) model of neurodevelopmental disorders. EE normalizes fine spike timing (FST) in the hippocampus, suggesting FST as a therapeutic target for cognitive impairments.

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