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Severe post-artesunate delayed onset anaemia responding to corticotherapy: a case report
Delphine Lebrun1,2, Thierry Floch3, Aurélie Brunet1
1Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims Teaching Hospitals, Reims, France.
Abstract:
Delayed onset haemolysis occurring post-artesunate and post-artemisinin combination therapy is secondary to delayed clearance of infected erythrocytes spared by pitting during treatment. We report a case of severe post-treatment delayed haemolytic anaemia with a positive direct antiglobulin test and a positive response to corticosteroid therapy, suggesting an associated immune mechanism.
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