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Sleep and cognitive decline: A prospective nondemented elderly cohort study
Seung Wan Suh1, Ji Won Han1, Ju Ri Lee1
1Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam.
Annals of Neurology
|February 3, 2018
Summary
Sleep disturbances like long sleep latency can predict cognitive decline in older adults. Specific sleep patterns may serve as early indicators for cognitive changes in normal cognition and mild cognitive impairment groups.
Area of Science:
- Neurology
- Gerontology
- Sleep Medicine
Background:
- Sleep disturbances are common in elderlies and may impact cognitive function.
- Understanding the relationship between sleep and cognition is crucial for early detection of cognitive decline.
Purpose of the Study:
- To investigate how sleep disturbances affect cognitive changes over a 4-year period in non-demented elderlies.
- To identify specific sleep parameters as potential early markers for cognitive decline.
Main Methods:
- A prospective cohort study of 2,238 normal cognition (NC) and 655 mild cognitive impairment (MCI) Korean elderlies.
- Sleep parameters (midsleep time, duration, latency, quality, efficiency, daytime dysfunction) and cognitive status were assessed at baseline and 4-year follow-up.
- Logistic regression models were used, adjusting for covariates like age, sex, education, and comorbidities.
Main Results:
- In NC participants, long sleep latency (>30 min), long sleep duration (≥7.95 hours), and late midsleep time were associated with cognitive decline.
- Newly developed long sleep latency doubled the risk of cognitive decline in NC individuals.
- In MCI participants, only long sleep latency was linked to a reduced chance of reverting to NC.
Conclusions:
- Long sleep latency is a potential early marker for cognitive decline in both normal cognition and mild cognitive impairment elderlies.
- Long sleep duration and early sleep times may specifically indicate cognitive decline risk in cognitively normal elderlies.
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