[Multimodality Therapy for Cecal Cancer with Peritoneal Dissemination]

Area of Science:

• Oncology
• Gastroenterology

Background:

• A 72-year-old male diagnosed with advanced cecal cancer (pT4N2M0H0P3, pStage IV) underwent ileocecal resection.
• The patient presented with peritoneal dissemination, a significant challenge in advanced colorectal cancer management.

Observation:

• Following initial surgery, the patient received extensive chemotherapy (106 courses of FOLFIRI plus Cetuximab) for peritoneal dissemination.
• Despite treatment, liver metastasis was detected 50 months post-resection and surgically removed in 2015.
• Further progression of peritoneal dissemination occurred 20 months after the second operation, necessitating a third surgical intervention.

Findings:

• The patient received additional chemotherapy (19 courses of FOLFIRI plus Cetuximab) after liver resection.
• Surgical resection of recurrent peritoneal dissemination was performed in 2016.
• The patient remained alive 81 months after the initial ileocecal resection, demonstrating long-term survival.

Implications:

• This case highlights the potential for long-term survival in patients with stage IV cecal cancer and extensive peritoneal dissemination.
• Aggressive multimodal treatment, including repeated chemotherapy and surgical resections, can be effective in managing refractory metastatic disease.
• Further research into optimal treatment strategies for such complex cases is warranted.