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Hyperglycaemia and Survival in Solid Tumours: A Systematic Review and Meta-analysis
R Barua1, A J Templeton2, B Seruga3
1Department of Medicine, University of Toronto, Toronto, Canada.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|February 4, 2018
Summary
High blood sugar (hyperglycaemia) is linked to worse survival and disease-free survival (DFS) in cancer patients. Further research is needed on managing blood sugar levels in cancer care.
Area of Science:
- Oncology
- Endocrinology
- Biostatistics
Background:
- Diabetes mellitus is known to worsen cancer outcomes.
- The impact of high blood sugar (hyperglycaemia) on cancer patients without diabetes remains unclear.
Purpose of the Study:
- To systematically evaluate the association between hyperglycaemia and cancer survival outcomes.
- To investigate the influence of hyperglycaemia on overall survival, disease-free survival (DFS), and progression-free survival (PFS).
Main Methods:
- A meta-analysis was conducted on 12 studies involving 9872 cancer patients.
- Data were pooled using random effects modeling to determine hazard ratios and confidence intervals.
- Subgroup analyses and meta-regression explored variations by hyperglycaemia measurement, cancer stage, and patient characteristics.
Main Results:
- Hyperglycaemia was significantly associated with poorer overall survival (HR 2.05) and DFS (HR 1.98).
- No significant association was found between hyperglycaemia and progression-free survival (PFS).
- The negative impact on overall survival persisted across different measurement methods and cancer stages.
Conclusions:
- Hyperglycaemia is a significant risk factor for adverse overall survival and DFS in cancer patients.
- The findings highlight the potential importance of glycaemic control in cancer management.
- Further investigation into the therapeutic role of glycaemic control in oncology is warranted.
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