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UGT polymorphisms and lamotrigine clearance during pregnancy.

Vaiva Petrenaite1, Inger Öhman2, Lena Ekström3

  • 1Epilepsy Clinic, Department of Neurology, University Hospital of Copenhagen, Rigshospitalet-Blegdamsvej and Glostrup, Denmark.

Epilepsy Research
|February 4, 2018
PubMed
Summary

Maternal UGT1A4 and UGT2B7 genetic variations, along with fetal sex, influence lamotrigine (LTG) clearance during pregnancy. Fetal sex significantly impacts LTG clearance changes throughout gestation.

Keywords:
LamotriginePolymorphismPregnancySex of foetusUGT

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