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Updated: Feb 15, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Serum protein marker panel for predicting preeclampsia.

Lifeng Cui¹, Chang Shu², Zitao Liu³

¹Department of Pathology, College of Basic Medical Sciences of Jilin University, Changchun, Jilin 130021, China.

Pregnancy Hypertension

|February 4, 2018

Summary

This summary is machine-generated.

This study identified novel serum protein markers for preeclampsia diagnosis and prediction of severe features. Key biomarkers include soluble epidermal growth factor receptor (sEGFR), which may play a role in preeclampsia pathogenesis.

Keywords:

Diagnostic biomarkers Diagnostics of preeclampsia Preeclampsia Pregnancy Severe features of preeclampsia

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Area of Science:

Obstetrics and Gynecology
Clinical Chemistry
Biomarker Discovery

Background:

Preeclampsia is a serious pregnancy complication lacking effective treatments.
Current preeclampsia diagnosis relies on clinical symptoms and standard lab tests.

Purpose of the Study:

To identify serum protein biomarkers for accurate preeclampsia diagnosis.
To discover markers for predicting the severity of preeclampsia features.

Main Methods:

172 pregnant women (110 preeclampsia, 62 controls) were analyzed.
Eleven serum proteins (VEGF, sFlt-1, sEndoglin, PlGF, sEGFR, prolactin, PTX3, PAI-1, NGAL, IL-27, COX-2) were quantified using Luminex and ELISA.

Main Results:

Seven proteins (sFlt-1, VEGF, sEndoglin, sEGFR, PlGF, NGAL, COX-2) showed correlation with preeclampsia.
VEGF, sEndoglin, PlGF, and sEGFR were identified as independent diagnostic factors.
sEndoglin, PTX3, and sFlt-1 correlated with severe preeclampsia features; serum creatinine, platelet count, and sEndoglin predicted severity.

Conclusions:

A panel of serum proteins (VEGF, sEndoglin, PlGF, sEGFR) can aid preeclampsia diagnosis.
Clinical variables (serum creatinine, platelet count) combined with sEndoglin predict severe preeclampsia.
Serum sEGFR is a potential novel biomarker involved in preeclampsia development.