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Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
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Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

Giuseppe Badalamenti1, Daniele Fanale1, Lorena Incorvaia1

  • 1Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90127 Palermo, Italy.

Cellular Immunology
|February 4, 2018
PubMed

Insights

Tumor-infiltrating lymphocytes (TILs) are key players in anti-tumor immunity. This review highlights their potential as biomarkers for predicting immunotherapy outcomes in solid tumors.

Area of Science:

  • Immunology
  • Oncology
  • Cancer Research

Background:

  • Immunotherapy has emerged as a validated treatment for various cancers, including melanoma, NSCLC, and RCC.
  • Cancer cells evade immune surveillance by utilizing immune checkpoint receptors to inhibit anti-tumor immune cells.
  • Tumor-infiltrating lymphocytes (TILs) represent a specialized T-cell population with heightened anti-tumor reactivity.

Purpose of the Study:

  • To review the role of TILs as biomarkers in cancer.
  • To explore the predictive potential of TILs for immunotherapy prognosis and clinical outcomes in solid tumors.

Main Methods:

  • Literature review of clinical studies and research on anti-tumor immunity.
  • Analysis of the mechanisms by which cancer cells interact with immune cells.
  • Examination of TILs as indicators of immune response and therapeutic efficacy.

Main Results:

  • TILs are crucial for eliciting anti-tumor immunity.
  • Immune checkpoints are exploited by tumors to suppress TIL activity.
  • TILs show promise as predictive biomarkers for immunotherapy.

Conclusions:

  • TILs are valuable biomarkers reflecting the immune response to tumors.
  • Assessing TILs can help predict prognosis and clinical outcomes of immunotherapy.
  • Further research into TILs can optimize cancer treatment strategies.
Keywords:
Immune suppressionImmunotherapyPD-1PD-L1Predictive significancePrognosisTumor immunologyTumor microenvironmentTumor-infiltrating lymphocytes (TILs)

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