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Related Concept Videos

Types of Fever01:25

Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
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Patterns of Fever01:26

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Inflammatory Response01:28

Inflammatory Response

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Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
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[Dermatological features of auto-inflammatory recurrent fevers].

A Escudier1, F-X Mauvais1, P Bastard2

  • 1Université de médecine Paris-Descartes, 12, rue de l'École-de-Médecine, 75006 Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|February 4, 2018
PubMed
Summary

Auto-inflammatory diseases involve recurrent inflammation due to innate immunity issues. Recognizing skin symptoms aids pediatricians in diagnosing these conditions early to prevent complications.

Keywords:
Auto-inflammatory diseasesDermatological manifestationsRecurrent fevers

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Area of Science:

  • Immunology
  • Dermatology
  • Genetics

Background:

  • Auto-inflammatory diseases are systemic inflammatory conditions originating from innate immunity dysregulation.
  • Recurrent inflammation affects skin, joints, and serosal membranes, requiring early clinical recognition, especially in pediatric patients.
  • Skin manifestations are key indicators for prompt diagnosis of these rare genetic disorders.

Purpose of the Study:

  • To review the pathophysiology of auto-inflammatory diseases.
  • To detail the main dermatological presentations of auto-inflammatory recurrent fevers.
  • To provide a decision tree for genetic testing in patients with recurrent fevers and skin symptoms.

Main Methods:

  • Physiopathological review of auto-inflammatory diseases.
  • Classification of dermatological manifestations associated with recurrent fevers.
  • Development of a clinical decision support tool for genetic testing.

Main Results:

  • Auto-inflammatory diseases stem from innate immunity dysfunction.
  • Common dermatological presentations include urticarial lesions, neutrophilic dermatoses, panniculitis, maculopapular eruptions, dyskeratosis, vasculitis, and oral aphthae.
  • A decision tree is proposed to guide genetic testing based on clinical presentation.

Conclusions:

  • Early diagnosis of auto-inflammatory diseases is crucial, particularly in pediatrics, to prevent severe complications.
  • Skin manifestations are vital clues for identifying patients with auto-inflammatory conditions.
  • The proposed decision tree can assist clinicians in selecting appropriate genetic tests for recurrent fevers with dermatological signs.