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Defining Substance Use Disorders: The Need for Peripheral Biomarkers
Kristopher J Bough1, Jonathan D Pollock1
1National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA), Rockville, MD 20852, USA.
Trends in Molecular Medicine
|February 4, 2018
Summary
Addiction, a brain disease, can be better understood by analyzing biological markers. Future research can use these biomarkers to develop new treatments for substance use disorders (SUDs).
Area of Science:
- Neuroscience
- Biomarker Discovery
- Addiction Research
Background:
- Addiction is recognized as a complex brain disease.
- Current diagnostic criteria for substance use disorders (SUDs) are primarily qualitative.
- Neurobiological research is advancing the characterization of addiction's underlying mechanisms.
Purpose of the Study:
- To explore the potential of peripheral biospecimens for deconstructing SUD heterogeneity.
- To propose the use of composite biomarkers for defining addiction endophenotypes.
- To highlight the opportunity for biomarker discovery in addiction research.
Main Methods:
- Examining various potential biomarker types from peripheral biospecimens.
- Applying advanced statistical and mathematical modeling techniques.
- Integrating multiple units of measure to analyze SUD characteristics.
Main Results:
- Peripheral biospecimens offer a pathway to understand SUD heterogeneity.
- Composite biomarkers can be discovered within specific addiction domains.
- Biomarker research holds promise for advancing drug development and medical care.
Conclusions:
- Combining biospecimen data and advanced modeling can lead to novel composite biomarkers for SUDs.
- These biomarkers may enable the definition of specific endophenotypes.
- This approach has significant implications for improving addiction treatment and drug development.
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