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[Topical use of prednicarbate preparations in children]
Zeitschrift Fur Hautkrankheiten
|January 1, 1986
Insights
Topical prednicarbate effectively treated inflammatory skin conditions in 50 children. This corticosteroid demonstrated a rapid onset of action with minimal risk to children's skin due to low systemic and antiproliferative effects.
Area of Science:
- Dermatology
- Pediatrics
- Pharmacology
Background:
- Inflammatory dermatoses are common in children.
- Topical corticosteroids are frequently used but carry risks.
- Prednicarbate is a newer topical corticosteroid with a potentially favorable safety profile.
Purpose of the Study:
- To evaluate the efficacy and safety of topical prednicarbate in pediatric patients with inflammatory dermatoses.
- To assess the onset of action and potential side effects of prednicarbate in children.
Main Methods:
- A study involving 50 children diagnosed with inflammatory dermatoses.
- Topical application of prednicarbate (Dermatop).
- Photographic documentation of treatment courses in 12 participants.
Main Results:
- Prednicarbate showed a rapid onset of therapeutic action.
- The treatment did not suppress endogenous cortisol biosynthesis.
- A minimal antiproliferative effect on cutaneous fibroblasts was observed.
Conclusions:
- Topical prednicarbate is effective for pediatric inflammatory dermatoses.
- Its favorable safety profile, including minimal systemic and local effects, makes it suitable for children's skin.
Abstract:
Prednicarbate (Dermatop) was topically applied in 50 children suffering from inflammatory dermatoses. In 12 children, the courses of therapy were documented by photographs. Its rapid onset of action, its lacking suppression of the endogenic biosynthesis of cortisol, as well as its small antiproliferative effect on cutaneous fibroblasts suggest that prednicarbate bears only minor risks especially for children's skin.