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Expression of gremlin1 in gastric cancer and its clinical significance

Yoichi Yamasaki1, Sumiya Ishigami2, Takaaki Arigami1

  • 1Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.

Medical Oncology (Northwood, London, England)
|February 4, 2018
PubMed

Insights

Gremlin1 expression in gastric cancer correlates with better prognosis and less aggressive features. This finding suggests gremlin1 may serve as a valuable diagnostic and therapeutic tool for stomach cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gastroenterology

Background:

  • Gremlin1 antagonizes bone morphogenetic proteins (BMPs), influencing organogenesis and tissue differentiation.
  • Its role in gastrointestinal cancer, particularly gastric cancer, remains largely unexplored.

Purpose of the Study:

  • To investigate the correlation between gremlin1 expression and the clinical features and biological properties of gastric cancer.
  • To assess the prognostic significance of gremlin1 in gastric cancer patients.

Main Methods:

  • Immunohistochemistry and western blotting were used to detect gremlin1 expression in 232 gastric cancer patients.
  • Clinicopathological parameters were analyzed for correlations with gremlin1 expression levels.

Main Results:

  • Gremlin1 was detected in gastric cancer tissues and cell lines.
  • Gremlin1 positivity was associated with shallower tumor depth, smaller tumor size, and reduced nodal and vessel invasion.
  • The 5-year survival rate was significantly higher in gremlin1-positive patients (81%) compared to gremlin1-negative patients.

Conclusions:

  • Gremlin1 expression in gastric cancer is linked to favorable clinicopathological features and improved survival.
  • While not an independent prognostic marker in multivariate analysis, gremlin1 shows potential as a prognostic indicator.
  • Gremlin1 may have future clinical applications in gastric cancer diagnosis and treatment, potentially through its involvement in the BMP signaling pathway.
Keywords:
Gastric cancerGremlin1ImmunohistochemistrySurvival

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