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Outcomes, Access, and Cost Issues Involving PCSK9 Inhibitors to Lower LDL-Cholesterol

Thomas F Whayne1

  • 1Gill Heart and Vascular Institute, University of Kentucky, 326 Wethington Building, 900 South Limestone Street, Lexington, KY, 40536-0200, USA. twhayn0@uky.edu.

Drugs
|February 4, 2018
PubMed

Insights

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors offer significant cardiovascular benefits for high-risk patients. Cost remains the primary barrier to their widespread clinical use, not efficacy.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are crucial for high-risk cardiovascular patients.
  • They are particularly beneficial for statin-intolerant individuals or those not reaching low-density lipoprotein cholesterol (LDL-C) goals.

Purpose of the Study:

  • To evaluate the established clinical importance and benefits of PCSK9 inhibitors in high-risk cardiovascular patients.
  • To identify the primary barriers to the appropriate clinical utilization of PCSK9 inhibitors.

Main Methods:

  • Review of clinical evidence supporting PCSK9 inhibitor efficacy.
  • Analysis of factors hindering patient access and approval processes.

Main Results:

  • The clinical benefit and LDL-C lowering effects of PCSK9 inhibitors are well-documented.
  • Cost is identified as the principal obstacle to appropriate clinical use, overshadowing efficacy concerns.

Conclusions:

  • The efficacy of PCSK9 inhibitors for high-risk cardiovascular patients is established.
  • Addressing cost and regulatory roadblocks is essential to improve patient access to these vital therapies.

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