Related Experiment Video
Updated: Feb 15, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Long-term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection
Hiva Saffar1, Ali-Reza Khalilian2, Mohammed-Jafar Saffar3
1Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Objective:
To determine the duration of protection conferred by the hepatitis B (HB) vaccination and the necessity of a booster dose.
Methods:
Immediately after the initial blood sampling, 252 youths (aged 18.8-20.5 years, 52% females) with a history of neonatal HB vaccination with one dose of the HB vaccine received a booster. Serum concentrations of antibodies against the HB surface antigen were assessed in samples collected before and 10-14 days after the booster. Seroconversion from concentrations <10 to ≥10 IU/L were defined as a positive immune response.
Results:
Of the 252 participants, 131 were sero-susceptible and 114 responded.
Conclusion:
Nearly 90% of young people preserved their long-term protection; the results of this study do not support the use of an HB booster vaccination.
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Dose-Response Relationship: Overview
Dose-Response Relationship: Potency and Efficacy
Dose-Response Relationship: Selectivity and Specificity
Dose Response Curve: Conventional Versus Nonmonotonic

