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Psoriasis and cardiovascular disease risk factors: the HUNT Study, Norway

I Snekvik1,2, T I L Nilsen1, P R Romundstad1

  • 1Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Journal of the European Academy of Dermatology and Venereology : JEADV
|February 4, 2018
PubMed

Insights

Psoriasis is linked to increased cardiovascular disease risk factors, particularly in severe cases. This study highlights associations with obesity and metabolic syndrome in a large population.

Area of Science:

  • Dermatology
  • Cardiology
  • Epidemiology

Background:

  • Conflicting evidence exists on psoriasis and cardiovascular disease (CVD) risk.
  • Previous studies often lack objective CVD risk factor measurements in general populations.

Purpose of the Study:

  • To examine the association between psoriasis severity and objectively measured CVD risk factors.
  • To investigate the link between psoriasis and cardiovascular morbidity in a large population-based cohort.

Main Methods:

  • Utilized data from the HUNT3 Study in Norway, linking it with national prescription records.
  • Included 50,245 participants, with 2,894 reporting psoriasis (2,643 mild, 251 moderate/severe).
  • Employed linear and logistic regression to analyze associations with CVD risk factors and morbidity.

Main Results:

  • Psoriasis showed positive associations with body mass index (BMI), waist circumference, and high-sensitivity C-reactive protein.
  • Moderate/severe psoriasis significantly increased odds of being overweight (OR 1.94) and having metabolic syndrome (OR 1.91).
  • Psoriasis was also linked to self-reported diabetes, myocardial infarction, and angina pectoris.

Conclusions:

  • Psoriasis is positively associated with adiposity and a cluster of CVD risk factors.
  • These associations are most pronounced in individuals with moderate to severe psoriasis.
  • Findings emphasize the importance of considering cardiovascular health in psoriasis management.
Abstract

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