Electroencephalography Source Functional Connectivity Reveals Abnormal High-Frequency Communication Among Large-Scale
Alexis E Whitton1, Stephanie Deccy2, Manon L Ironside2
1Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|February 5, 2018
Summary
Major depressive disorder (MDD) is linked to increased high-frequency brain connectivity within the default mode network (DMN) and between the DMN and frontoparietal network (FPN). This hyperconnectivity may indicate a more recurrent course of illness.
Area of Science:
- Neuroscience
- Psychiatry
- Brain Imaging
Background:
- Major depressive disorder (MDD) is associated with altered resting-state functional connectivity, particularly within the default mode network (DMN) and between the DMN and frontoparietal network (FPN).
- Previous research has primarily focused on low-frequency connectivity, leaving higher frequency synchronization patterns in MDD largely unexplored.
- Understanding these high-frequency abnormalities is crucial for elucidating the neurophysiological underpinnings of disrupted functional connectivity in MDD.
Purpose of the Study:
- To investigate abnormalities in high-frequency (>1 Hz) resting-state functional connectivity in individuals with MDD.
- To compare spectral properties of functional connectivity between individuals with MDD, healthy controls, and individuals in remission from depression.
- To explore the relationship between high-frequency connectivity disturbances and illness characteristics, such as recurrence.
Main Methods:
- Utilized electroencephalography (EEG) for its high temporal resolution to assess spectral properties of resting-state functional connectivity.
- Employed exact low-resolution electromagnetic tomography (eLORETA) to compute intracortical activity within the DMN and FPN.
- Calculated functional connectivity using lagged phase synchronization in three groups: MDD (n=65), healthy controls (n=79), and remitted MDD (n=30).
Main Results:
- Individuals with MDD exhibited significantly greater within-DMN beta 2 band (18.5-21 Hz) connectivity compared to controls.
- The MDD group also showed increased beta 1 band (12.5-18 Hz) connectivity between the DMN and FPN, which was not present in the remitted group.
- Higher beta 1 band DMN-FPN connectivity correlated with a greater number of depressive episodes, independent of current symptom severity.
Conclusions:
- Elevated high-frequency connectivity within the DMN and between the DMN and FPN are characteristic of MDD.
- These high-frequency connectivity alterations are not observed in individuals with MDD in remission.
- Increased beta 1 band DMN-FPN connectivity may serve as a neural marker associated with a more recurrent pattern of major depressive disorder.
Keywords:
Default mode networkFrontoparietal networkLagged phase synchronizationMajor depressive disorderResting-state functional connectivityeLORETAMore Related Videos
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