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Identification of Circular RNAs using RNA Sequencing
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Stable Intronic Sequence RNAs Engage in Feedback Loops.

Jun Wei Pek1

  • 1Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604.

Trends in Genetics : TIG
|February 5, 2018
PubMed
Summary
This summary is machine-generated.

Stable intronic sequence RNAs (sisRNAs) are conserved across organisms. These molecules may generally regulate gene expression through feedback loops, acting as local control mediators.

Keywords:
feedbackgene expressionintronnoncoding RNAsisRNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • RNA Biology

Background:

  • Stable intronic sequence RNAs (sisRNAs) are conserved RNA molecules found across diverse species.
  • Emerging evidence suggests sisRNAs play regulatory roles in gene expression.

Purpose of the Study:

  • To investigate the potential of sisRNAs as general mediators of local gene expression feedback control.
  • To explore the conserved nature and regulatory functions of sisRNAs.

Main Methods:

  • Comparative analysis of sisRNA conservation across organisms.
  • Functional studies in Drosophila to elucidate sisRNA-gene interactions.
  • Gene expression analysis to assess regulatory feedback loops.

Main Results:

  • sisRNAs are conserved in various organisms, indicating fundamental biological importance.
  • Observations in Drosophila demonstrate sisRNAs participating in regulatory feedback loops.
  • These feedback loops involve sisRNAs controlling the expression of their parental genes.

Conclusions:

  • sisRNAs are conserved regulatory elements with a role in gene expression.
  • The mechanism of sisRNAs mediating local feedback control may be a widespread phenomenon in biology.