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Hydrops fetalis and chromosomal trisomies.
American Journal of Obstetrics and Gynecology
|May 1, 1986
Summary
Chromosomal trisomies, like Down syndrome (trisomy 21), occur in 7% of infants with nonimmunologic hydrops fetalis. This highlights the importance of genetic testing for affected newborns to identify these chromosomal disorders.
Area of Science:
- Genetics
- Neonatal Medicine
- Perinatology
Background:
- Nonimmunologic hydrops fetalis is a serious condition in newborns.
- Chromosomal abnormalities are a known, but not fully quantified, cause of nonimmunologic hydrops fetalis.
Purpose of the Study:
- To determine the incidence of chromosomal trisomies in nonimmunologic hydrops fetalis.
- To emphasize the clinical utility of chromosomal analysis in neonates diagnosed with nonimmunologic hydrops fetalis.
Main Methods:
- Case presentation of three patients with trisomy 21 and one with trisomy 13 associated with nonimmunologic hydrops fetalis.
- Retrospective analysis of previous studies on nonimmunologic hydrops fetalis including chromosomal trisomies.
Main Results:
- The combined analysis of previous and current data indicates a 7% incidence of chromosomal trisomy disorders in live-born infants with nonimmunologic hydrops fetalis.
- Trisomy 21 and trisomy 13 were identified as specific chromosomal abnormalities associated with this condition.
Conclusions:
- Chromosomal trisomies represent a significant etiology of nonimmunologic hydrops fetalis.
- Routine chromosomal analysis is crucial for neonates presenting with nonimmunologic hydrops fetalis for accurate diagnosis and management.