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Impact of different antihypertensives on carotid arterial wall thickness

Ki-Hong Kim1, In Geol Song1, Taek-Geun Kwon1

  • 1Department of Cardiology, Konyang University Hospital, Daejeon, Korea.

Journal of Clinical Hypertension (Greenwich, Conn.)
|February 5, 2018
PubMed

Insights

Hypertension is linked to thicker carotid intima media thickness. This study found beta-blockers may be associated with increased carotid wall thickness in hypertensive patients.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Hypertension is a known risk factor for atherosclerosis and cardiovascular disease.
  • Increased carotid intima-media thickness (CIMT) is observed in hypertensive individuals.
  • The relationship between CIMT and specific antihypertensive agents remains unclear.

Purpose of the Study:

  • To investigate the correlation between carotid intima-media thickness (CIMT) and different classes of antihypertensive agents.
  • To determine if specific antihypertensive medications influence CIMT in hypertensive patients.

Main Methods:

  • A study involving 1809 patients was conducted.
  • Carotid intima-media thickness (CIMT) was measured and compared between hypertensive and non-hypertensive groups.
  • Multivariate analysis was performed to assess the association between CIMT and antihypertensive agents, specifically beta-blockers.

Main Results:

  • Hypertensive patients exhibited significantly thicker CIMT compared to non-hypertensive individuals across multiple measurements (e.g., 0.72 ± 0.17 mm vs 0.64 ± 0.15 mm, P < .001).
  • Hypertensive patients treated with beta-blockers showed increased CIMT compared to those not on beta-blockers (e.g., 0.74 ± 0.18 mm vs 0.71 ± 0.16 mm, P = .018).
  • Multivariate analysis indicated a significant correlation between higher CIMT and the use of beta-blockers (odds ratio = 2.489, P = .016).

Conclusions:

  • Hypertension is associated with increased carotid intima-media thickness.
  • Beta-blocker use in hypertensive patients may be linked to a greater carotid wall thickness.
  • Further research is warranted to elucidate the specific mechanisms and clinical implications of beta-blockers on CIMT.

Keywords:
antihypertensive agentsatherosclerosishypertensionultrasonography

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