Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

709
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
709
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

824
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
824
Long-term Depression01:05

Long-term Depression

33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
Long-term Depression01:03

Long-term Depression

3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.4K
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

41.3K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
41.3K
Depressants01:28

Depressants

481
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
481

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Life's Essential 8 and Suicide Risk: A Population-Level Study of Cardiovascular Health as a Mental Health Indicator.

Psychiatry investigation·2026
Same author

Dexamethasone-induced 3D cortical spheroid model of stress-related neuroplasticity impairment.

Scientific reports·2026
Same author

Permutation entropy analysis of EEG during a Go/No-Go task to differentiate patients with suicide attempt from those with suicidal ideation in major depressive disorder.

European archives of psychiatry and clinical neuroscience·2026
Same author

Korean Medication Algorithm Project for Depressive Disorder 2025: Comparisons with Other Treatment Guidelines.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2026
Same author

Clinical significance of nocturnal sleep onset REM periods in narcolepsy diagnosis and diagnostic stability.

Sleep and biological rhythms·2026
Same author

EEG microstate and functional connectivity analyses for differentiating suicide attempt from suicidal ideation in major depressive disorder.

Journal of psychiatry & neuroscience : JPN·2025
Same journal

Psychosis in a 47,XXX Adolescent: Clinical Management and Multidisciplinary Follow-up.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2026
Same journal

Guanfacine as a Treatment Option for Persistent Mental Restlessness and Deliberate Self-harm Thoughts in a Patient with Attention-deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Borderline Personality Disorder, and Post-traumatic Stress Disorder: Case Report.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2026
Same journal

Delirious Mania with Mild Encephalitis and a Reversible Splenial Lesion Successfully Treated with Electroconvulsive Therapy: A Case Report.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2026
Same journal

Time-limited Moderating Effect of Neuroticism on the Cortisol-Depression Relationship after Physical Injury.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2026
Same journal

Antibiotic-induced Microbiome Depletion Selectively Reduces Baseline Hypothalamic Oxytocin Signaling without Affecting MDMA-induced Oxytocin Response in Rats.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2026
Same journal

Early Individualized Psychological Intervention Using Virtual Reality-assisted Decision System Reduces Decisional Conflict in Patients with Pulmonary Nodules: A Randomized Controlled Trial.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.6K

Korean Medication Algorithm for Depressive Disorders 2017: Third Revision.

Jeong Seok Seo1, Won-Myong Bahk2, Hee Ryung Wang2

  • 1Department of Psychiatry, Konkuk University School of Medicine, Cheongju, Korea.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|February 6, 2018
PubMed
Summary
This summary is machine-generated.

This study updates Korean guidelines for major depressive disorder (MDD) treatment. Antidepressant monotherapy is preferred for most MDD cases, with atypical antipsychotics increasingly used for specific presentations.

Keywords:
AlgorithmsDepressive disorderDrug therapyGuideline

More Related Videos

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

14.7K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.5K

Related Experiment Videos

Last Updated: Feb 15, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.6K
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

14.7K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.5K

Area of Science:

  • Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • The Korean Society for Affective Disorders established guidelines for major depressive disorder (MDD) treatment in 2002, with subsequent revisions in 2006 and 2012.
  • The field of affective disorders has advanced, necessitating a third revision of the existing guidelines.

Purpose of the Study:

  • To update and revise the clinical practice guidelines for the treatment of major depressive disorder (MDD).
  • To reflect recent advances in pharmacological and non-pharmacological treatment strategies for MDD.

Main Methods:

  • An expert consensus was gathered using a 44-item questionnaire.
  • The consensus covered pharmacological strategies for various MDD presentations, including psychotic features, subtypes, maintenance, special populations, and antidepressant selection based on safety and adverse effects.
  • Non-pharmacological biological therapies were also assessed, with statistically derived first, second, and third-line treatment recommendations.

Main Results:

  • Antidepressant (AD) monotherapy is the recommended first-line strategy for adult, pediatric, elderly, persistent depressive disorder, and pregnant/postpartum patients.
  • Combination therapy with AD and atypical antipsychotics (AAP) is recommended for psychotic depression, postpartum depression, and cases with mixed features or anxious distress.
  • Electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS) are increasingly considered, though clinical application rates vary.

Conclusions:

  • The 2017 pharmacological treatment strategies align with the 2012 Korean Medication Algorithm for Depressive Disorder.
  • There is an increased preference for the use of atypical antipsychotics (AAPs) in the updated guidelines.