Related Experiment Video

Updated: Feb 15, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

14.9K

Utility of additional dedicated high-resolution 3T MRI in children with medically refractory focal epilepsy

Raheel Ahmed1, Luc Rubinger2, Cristina Go3

  • 1Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

Epilepsy Research
|February 6, 2018
PubMed
Abstract

Insights

High-resolution 3T MRI improves detection of cryptic lesions in children with epilepsy, aiding surgical management. This advanced imaging helps identify subtle abnormalities missed by standard protocols, leading to better seizure control.

Area of Science:

  • Neuroradiology
  • Epileptology
  • Pediatric Neurology

Background:

  • Medically refractory epilepsy often requires surgical intervention.
  • Standard MRI may fail to detect subtle lesions in some epilepsy cases.
  • High-resolution MRI offers potential for improved lesion detection.

Purpose of the Study:

  • To evaluate the effectiveness of high-resolution dedicated 3T MRI in identifying cryptic lesions.
  • To assess the impact of advanced MRI on clinical management in children with refractory epilepsy.
  • To determine if high-resolution MRI improves lesion detection in patients with initially normal MRI scans.

Main Methods:

  • Inclusion of pediatric patients with refractory epilepsy and normal or suspected focal cortical dysplasia (FCD) on standard 3T MRI.
  • Exclusion of patients with tumors or hippocampal sclerosis.
  • Performance of dedicated high-resolution 3T MRI guided by video EEG, MEG, and FDG-PET in patients with normal initial MRI.

Main Results:

  • High-resolution MRI identified lesions in 66% of patients with initially normal scans.
  • The addition of high-resolution MRI increased lesion detection sensitivity from 53.1% to 85.9%.
  • Identified lesions guided surgical resection and depth electrode placement in a significant majority of cases.

Conclusions:

  • High-resolution dedicated MRI is valuable for identifying lesions in non-lesional epilepsy cases on standard MRI.
  • This advanced imaging technique can significantly impact surgical management decisions.
  • Improved lesion detection through high-resolution MRI may lead to better seizure control in pediatric epilepsy patients.
Keywords:
3T MRIDiagnostic efficacyPediatric refractory epilepsySeizure freedom

More Related Videos

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

2.5K
Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings08:20

Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings

Published on: June 6, 2015

15.9K

Related Concept Videos

Conjugate Addition (1,4-Addition) vs Direct Addition (1,2-Addition)01:27

Conjugate Addition (1,4-Addition) vs Direct Addition (1,2-Addition)

α,β-Unsaturated carbonyl compounds with two electrophilic sites, the carbonyl carbon, and the β carbon, are susceptible to nucleophilic attack via two modes: conjugate or 1,4-addition and direct or 1,2-addition.
Conjugate addition results in a thermodynamically stable product. The reaction retains the stronger C=O bond at the expense of the weaker C=C π bond. The process is slow as the β carbon is less electrophilic than the carbonyl carbon.
Direct addition products are...
4.4K
Conjugate Addition of Enolates: Michael Addition01:08

Conjugate Addition of Enolates: Michael Addition

The attack of a nucleophile at the β carbon of an α,β-unsaturated carbonyl compound is called conjugate addition. Conjugate addition reactions of active methylene compounds, such as β-diketones, β-keto esters, β-keto nitriles, and α-nitro ketones, are called Michael addition reactions.
3.7K
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
840
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.4K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.7K
Additives and Fillers in Concrete01:29

Additives and Fillers in Concrete

Additives and fillers are integral to enhancing the properties of concrete. Pozzolans and blast-furnace slag are additives or admixtures due to their reactions with calcium hydroxide released during cement hydration. Fillers, which are finely ground and similar in fineness to Portland cement, improve concrete attributes such as workability density, and reduce capillary bleeding or cracking. Some fillers possess hydraulic properties or participate in benign reactions within the cement paste.
The...
374