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The Basal Forebrain Regulates Global Resting-State fMRI Fluctuations
Janita Turchi1, Catie Chang2, Frank Q Ye3
1Laboratory of Neuropsychology, NIMH, NIH, NIH, Bethesda, MD 20892 USA.
Neuron
|February 6, 2018
Summary
The nucleus basalis of Meynert (NBM) selectively impacts global brain activity patterns, not specific resting-state networks. This study reveals the NBM's role in coordinating widespread brain fluctuations.
Area of Science:
- Neuroscience
- Functional Neuroimaging
Background:
- Spontaneous brain activity, measured by fMRI, reveals functional organization but underlying mechanisms are unclear.
- The nucleus basalis of Meynert (NBM) is a key source of cholinergic and GABAergic projections to the cortex.
Purpose of the Study:
- To investigate the hypothesis that the NBM critically contributes to spontaneous brain activity patterns.
- To elucidate the NBM's role in generating and coordinating neural fluctuations.
Main Methods:
- Reversible inactivation of two distinct NBM sites in macaques.
- Simultaneous measurement of whole-brain fMRI activity.
Main Results:
- NBM inactivation caused significant, localized suppression of global signal components in the ipsilateral cortex.
- Resting-state networks maintained their spatial structure despite the suppression of global signals.
Conclusions:
- The NBM selectively contributes to the global component of functional connectivity.
- The NBM plays a minimal role in the specific correlations defining resting-state networks.
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