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Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments
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Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly

Martin Jacko1, Sebastien M Weyn-Vanhentenryck2, John W Smerdon3

  • 1Departments of Systems Biology and Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA; Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Center for Motor Neuron Biology and Disease, Columbia Stem Cell Initiative, Columbia University, New York, NY 10032, USA.

Neuron
|February 6, 2018
PubMed
Summary

Rbfox proteins are crucial for neuronal maturation. Their depletion impairs splicing and electrical activity, affecting the axon initial segment and overall neuron development.

Keywords:
AnkGRbfoxactin cytoskeletonalternative splicingaxon initial segmentneuronal maturation

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