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Linking diabetic vascular complications with LncRNAs
Amy Leung1, Vishnu Amaram2, Rama Natarajan2
1Department of Diabetes Complications and Metabolism, Diabetes and Metabolic Research Institute, 1500 East Duarte Road, Duarte, CA 91010, United States.
Vascular Pharmacology
|February 6, 2018
Summary
Diabetes accelerates vascular complications like hypertension and retinopathy. Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in diabetic vascular disease, offering potential therapeutic targets.
Area of Science:
- Vascular Biology
- Molecular Medicine
- Genomics
Background:
- Diabetes mellitus significantly accelerates macrovascular (hypertension, atherosclerosis) and microvascular (nephropathy, retinopathy) complications.
- Hyperglycemia in diabetes induces cellular changes in vascular and inflammatory cells, promoting disease progression.
- Understanding the molecular mechanisms underlying diabetic vascular complications is crucial for developing novel therapies.
Purpose of the Study:
- To review the role of long-noncoding RNAs (lncRNAs) in vascular cell biology.
- To summarize the involvement of lncRNAs in the pathogenesis of diabetic vascular complications.
Main Methods:
- Literature review of studies investigating lncRNAs in vascular cells.
- Literature review of studies linking lncRNAs to diabetic vascular complications.
Main Results:
- lncRNAs play significant roles in the normal biology of vascular cells.
- Emerging evidence implicates specific lncRNAs in the development and progression of diabetic vascular complications.
Conclusions:
- lncRNAs represent a critical and understudied area in diabetic vascular disease.
- Further research into lncRNA function may unveil new therapeutic strategies for diabetic complications.
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