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Related Concept Videos

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Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
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The MINDVIEW project: First results.

José M Benlloch1, Antonio J González1, Roberto Pani2

  • 1Institute for Instrumentation in Molecular Imaging (I3 M), Universidad Politécnica de Valencia - CSIC, Valencia, Spain.

European Psychiatry : the Journal of the Association of European Psychiatrists
|February 6, 2018
PubMed
Summary
This summary is machine-generated.

The MINDVIEW project developed an advanced PET/MRI brain scanner with higher sensitivity and resolution. This system aids schizophrenia research by enabling detailed brain imaging and identifying potential immune cell alterations in early-stage patients.

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Radiochemistry

Background:

  • Schizophrenia diagnosis and research require advanced brain imaging techniques.
  • Simultaneous Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) offer complementary information.
  • Existing systems face limitations in sensitivity, resolution, and cost-effectiveness.

Purpose of the Study:

  • To present the initial findings from the MINDVIEW project.
  • To introduce a novel integrated PET/MRI system for brain examination.
  • To evaluate the system's performance and its application in schizophrenia research.

Main Methods:

  • Designed and constructed a novel head-dedicated radio frequency coil for a 3T MRI scanner, integrating a high-sensitivity, high-resolution PET scanner.
  • Developed a cost-effective method for producing the radiopharmaceutical 11C-carbon monoxide.
  • Utilized 11C-raclopride for PET imaging in a VAAT null mutant mouse model and in drug-naïve, first episode psychosis patients.

Main Results:

  • The PET scanner exhibits 3 times higher sensitivity than current systems, allowing for safer repeated patient studies.
  • Achieved spatial resolution close to 1 mm, enabling differentiation of critical brain structures.
  • Demonstrated higher binding potential of 11C-raclopride in a novel mouse model of schizophrenia.
  • Observed reduced TSPO binding in the gray matter of early-stage psychosis patients, suggesting altered immune cell activity.

Conclusions:

  • The MINDVIEW integrated PET/MRI system represents a significant advancement in brain imaging technology.
  • The system's high sensitivity and resolution are well-suited for detailed neuroimaging in conditions like schizophrenia.
  • Preliminary results suggest potential utility in understanding the pathophysiology of schizophrenia, including immune system involvement.