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Published on: August 7, 2018
Oxidation of Vicinal Diols to α-Hydroxy Ketones with H2O2 and a Simple Manganese Catalyst
Francesco Mecozzi1, Jia Jia Dong1, Pattama Saisaha1
1Molecular Inorganic Chemistry Stratingh Institute for Chemistry Faculty of Mathematics and Natural Sciences Nijenborgh 49747 AG Groningen The Netherlands.
Abstract:
α-Hydroxy ketones are valuable synthons in organic chemistry. Here we show that oxidation of vic-diols to α-hydroxy ketones with H2O2 can be achieved with an in situ prepared catalyst based on manganese salts and pyridine-2-carboxylic acid. Furthermore the same catalyst is effective in alkene epoxidation, and it is shown that alkene oxidation with the MnII catalyst and H2O2 followed by Lewis acid ring opening of the epoxide and subsequent oxidation of the alkene to α-hydroxy ketones can be achieved under mild (ambient) conditions.
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