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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Plant flavone apigenin: An emerging anticancer agent.

Eswar Shankar^1,2, Aditi Goel³, Karishma Gupta^1,2

¹Department of Urology, The James and Eilleen Dicke Laboratory, Case Western Reserve University, Cleveland, OH 44106, USA.

Current Pharmacology Reports

|February 6, 2018

Summary

Apigenin, a plant flavone, shows promise in cancer prevention and treatment due to its antioxidant and anti-inflammatory effects. Further research is needed to address limitations for human trials.

Keywords:

cancer chemoprevention dietary agents health effects nanoparticle plant flavonoids polyphenols

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Published on: May 28, 2014

Area of Science:

Oncology
Pharmacology
Nutritional Science

Background:

Fruits and vegetables contain phytochemicals with anti-inflammatory and antioxidant properties.
Flavonoids, a class of phytochemicals, show potential as cancer chemopreventive agents.
Apigenin is a prominent flavone with demonstrated antioxidant, anti-inflammatory, and anticancer activities.

Purpose of the Study:

To review the anticancer role of apigenin.
To highlight apigenin's potential as a chemopreventive and therapeutic agent.
To discuss current limitations for apigenin's use in human trials.

Main Methods:

Review of epidemiological and case-control studies on apigenin.
Analysis of preclinical studies on apigenin's mechanisms of action.
Pharmacokinetic evaluation of apigenin's bioavailability and metabolism.

Main Results:

Apigenin intake is associated with reduced risk of certain cancers.
Apigenin exhibits potent therapeutic effects alone and enhances chemotherapy efficacy.
Apigenin shows minimal toxicity to normal cells with favorable pharmacokinetic properties.

Conclusions:

Apigenin possesses significant anticancer potential as both a preventive and therapeutic agent.
Apigenin's unique properties contribute to its anticancer effects and bioavailability.
Caveats currently limit the direct application of apigenin in human clinical trials.