Dissecting the Role of Disturbed ER-Golgi Trafficking in Antivirals and Alcohol Abuse-Induced Pathogenesis of Liver Disorders
1Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.
Journal of Drug Abuse
|February 6, 2018
Abstract:
Antiviral drugs and alcohol abuse-induced organelle stresses have been linked to many disorders and the underlying molecular mechanisms are under intense investigations. This brief review communicates emerging evidence and research trends on how certain antivirals and alcohol affect ER-Golgi trafficking, which potentially impacts the function and integrity of the Golgi apparatus contributing to endoplasmic reticulum stress and cellular injury.
Insights
Certain antivirals and alcohol disrupt endoplasmic reticulum-Golgi trafficking, impacting cellular integrity. This review explores these organelle stresses and their links to various disorders.
Area of Science:
- Cellular Biology
- Molecular Mechanisms
- Drug-Induced Toxicity
Background:
- Antiviral drugs and alcohol abuse are associated with various health disorders.
- The molecular mechanisms underlying these conditions, particularly organelle stress, are under investigation.
- Endoplasmic reticulum (ER) and Golgi apparatus dysfunction are implicated in cellular injury.
Purpose of the Study:
- To review emerging evidence on how antivirals and alcohol affect ER-Golgi trafficking.
- To highlight the impact of these disruptions on Golgi apparatus function and integrity.
- To connect these cellular events to endoplasmic reticulum stress and cellular injury.
Main Methods:
- Literature review of recent research trends.
- Analysis of studies investigating ER-Golgi trafficking pathways.
- Examination of molecular mechanisms linking drug/alcohol effects to organelle stress.
Main Results:
- Certain antivirals and alcohol significantly alter ER-Golgi trafficking.
- These alterations compromise the structure and function of the Golgi apparatus.
- Disrupted trafficking contributes to endoplasmic reticulum stress and subsequent cellular damage.
Conclusions:
- ER-Golgi trafficking is a critical cellular process affected by antivirals and alcohol.
- Understanding these mechanisms can provide insights into drug-induced and alcohol-related disorders.
- Further research is needed to fully elucidate these complex molecular pathways.
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