Related Experiment Video
Updated: Feb 15, 2026
06:40
Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells
Published on: September 15, 2014
17.2K
Camptocormia Induced by a Dopaminergic Agonist
1Departments of Neuromodulation and Neurosurgery, Osaka University Graduate School of Medicine; and †Center for Information and Neural Networks (CiNet), Osaka University, Suita, Osaka, Japan.
Clinical Neuropharmacology
|February 6, 2018
Summary
Dopaminergic agonists may trigger camptocormia, a forward-bending posture, even in non-Parkinson disease patients. Discontinuing these drugs can reduce camptocormia symptoms, suggesting a potential drug-induced cause.
Area of Science:
- Neurology
- Movement Disorders
Background:
- Camptocormia, characterized by abnormal trunk flexion, is frequently observed in Parkinson disease (PD).
- The precise mechanisms and etiology of camptocormia remain debated.
- Dopaminergic agonists (DAs) are a common treatment for PD symptoms.
Observation:
- A case report details a non-PD patient who developed intermittent camptocormia after initiating DA treatment.
- The patient experienced significant falls over an 8-year period due to the condition.
- Camptocormia symptoms improved after the cessation of DA therapy.
Findings:
- This case implicates dopaminergic agonists in the onset of camptocormia in a patient without PD.
- The temporal relationship suggests a potential drug-induced etiology for camptocormia episodes.
Implications:
- Clinicians should consider drug-induced camptocormia in both PD and non-PD patients on DA treatment.
- This highlights the need for careful consideration and monitoring when prescribing DAs.
More Related Videos
Related Concept Videos
01:30Adrenergic Agonists: Therapeutic Uses
2.0K
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
2.0K
01:24Glucagon-like Receptor Agonists
1.0K
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
1.0K
01:25Drug-Receptor Interaction: Agonist
4.2K
Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous...
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous...
4.2K
01:18Adrenergic Agonists: Therapeutic Classification
1.7K
Adrenergic agonists can be classified based on their therapeutic uses and mechanisms of action. They serve various purposes in clinical applications.
Vasopressor or pressor agents: They increase blood pressure and function as cardiac stimulants. Examples include endogenous catecholamines (norepinephrine and dopamine) and synthetic agents (phenylephrine).
Bronchodilators: β2-agonists can relax bronchial muscles and widen airways. They are commonly used for treating obstructive pulmonary...
Vasopressor or pressor agents: They increase blood pressure and function as cardiac stimulants. Examples include endogenous catecholamines (norepinephrine and dopamine) and synthetic agents (phenylephrine).
Bronchodilators: β2-agonists can relax bronchial muscles and widen airways. They are commonly used for treating obstructive pulmonary...
1.7K
01:31Direct-Acting Cholinergic Agonists: Pharmacokinetics
1.9K
Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
1.9K
01:11Direct-Acting Cholinergic Agonists: Therapeutic Uses
1.8K
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
1.8K