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Related Experiment Videos

Friction from Transduction Channels' Gating Affects Spontaneous Hair-Bundle Oscillations.

Jérémie Barral1, Frank Jülicher2, Pascal Martin3

  • 1Laboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, UMR168, Paris, France; UPMC Université Paris 06, Sorbonne Universités, Paris, France.

Biophysical Journal
|February 6, 2018
PubMed
Summary

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Friction from delayed ion channel gating significantly impacts inner ear hair cell oscillations. This channel kinetics, not just fluid viscosity, shapes oscillation waveforms and tunes characteristic frequencies.

Area of Science:

  • Auditory Neuroscience
  • Biophysics
  • Cellular Mechanics

Background:

  • Inner ear hair cells exhibit spontaneous oscillations, amplifying weak sound stimuli.
  • Delayed gating of mechanosensitive ion channels introduces friction, a poorly understood factor in hair bundle motility.

Purpose of the Study:

  • To investigate the role of friction, specifically from channel gating, in spontaneous hair bundle oscillations.
  • To determine how endolymph viscosity and channel kinetics influence hair bundle dynamics.

Main Methods:

  • Characterized oscillation properties in individual hair cells across a large ensemble.
  • Measured the effect of varying endolymph viscosity on oscillation properties.
  • Employed stochastic simulations incorporating friction to model observed behaviors.

Related Experiment Videos

Main Results:

  • Hair bundle movements were too slow for viscous drag alone to be significant.
  • Oscillation frequency was minimally affected by a 30-fold increase in viscosity.
  • Simulations required 3-8 times more friction than viscous drag to match experimental data, attributed to channel gating delays.
  • Inferred a channel activation time of ~1 ms, which influences hair bundle dynamics despite being shorter than the oscillation period.

Conclusions:

  • Friction arising from transduction channel gating kinetics is a critical determinant of hair bundle oscillation waveform.
  • Channel activation time acts as a tuning mechanism for the characteristic frequency of hair cells.
  • The kinetics of transduction channel gating are fundamental to spontaneous hair bundle oscillations.