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Related Experiment Video

Updated: Feb 15, 2026

De Novo Generation of Somatic Stem Cells by YAP/TAZ
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Skeletal cell YAP and TAZ combinatorially promote bone development.

Christopher D Kegelman1,2,3, Devon E Mason1,3, James H Dawahare3

  • 1Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|February 7, 2018
PubMed
Summary

Skeletal cells

Keywords:
osteoblastsosteogenesisosteoprogenitor cellstranscriptional regulation

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Area of Science:

  • Bone biology and skeletal development.

Background:

  • The roles of Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in bone formation are debated.
  • Previous studies reported conflicting effects of YAP and TAZ on osteogenesis, with unclear combinatorial functions.

Purpose of the Study:

  • To investigate the combined roles of YAP and TAZ in skeletal lineage cells during bone development.
  • To elucidate the impact of YAP/TAZ deletion on bone accrual, material properties, and cellular activity.

Main Methods:

  • Utilized Osterix-Cre mice for conditional deletion of YAP and TAZ in skeletal lineage cells.
  • Assessed bone phenotypes, including bone accrual, material properties, collagen organization, and fracture incidence.
  • Analyzed cellular activity (osteoblasts and osteoclasts) and gene expression related to osteogenesis and collagen.

Main Results:

  • Combinatorial deletion of YAP/TAZ resulted in an osteogenesis imperfecta-like phenotype, with severity linked to allele dose.
  • YAP/TAZ ablation decreased bone accrual and impaired bone material properties due to reduced collagen content and organization.
  • Reduced osteoblast activity and increased osteoclast activity were observed, leading to impaired bone remodeling and spontaneous fractures.

Conclusions:

  • YAP and TAZ function combinatorially to promote bone development.
  • These coactivators regulate osteoblast activity, bone matrix quality, and osteoclast-mediated remodeling.
  • Understanding YAP/TAZ roles is crucial for addressing bone development disorders.