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Robust label-free biosensing using microdisk laser arrays with on-chip references.

S F Wondimu, M Hippler, C Hussal

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    Summary
    This summary is machine-generated.

    This study introduces a new referencing method for whispering-gallery mode (WGM) microdisk lasers, enabling stable, highly sensitive biosensing by simultaneously compensating for temperature drift and photobleaching in sensor arrays.

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    Area of Science:

    • Optoelectronics
    • Nanotechnology
    • Biomedical Sensing

    Background:

    • Whispering-gallery mode (WGM) microdisk lasers offer high sensitivity for label-free detection in sensor arrays.
    • Practical applications are hindered by temperature fluctuations and photobleaching, affecting device performance.

    Purpose of the Study:

    • To develop a novel referencing scheme for WGM microdisk lasers to overcome temperature drift and photobleaching.
    • To enable robust and sensitive label-free biosensing under ambient conditions.

    Main Methods:

    • Implementation of a referencing scheme using protected reference structures with local passivation.
    • Simultaneous compensation of temperature drift and photobleaching in WGM devices.
    • Experimental validation of the referencing technique in extended sensor arrays.

    Main Results:

    • Demonstrated robust and sensitive label-free detection across varying temperatures.
    • Achieved simultaneous compensation of both photobleaching and temperature drift.
    • Successfully scaled the technique for arrays of hundreds of devices.

    Conclusions:

    • The novel referencing scheme effectively addresses key limitations of WGM microdisk lasers for practical sensing.
    • This represents the first demonstration of simultaneous compensation for photobleaching and temperature drift in active WGM biosensing devices.