Donor Body Mass Index as a Risk Factor for Delayed Onset of Graft Function

Juraj Miklušica1, Ivana Dedinská1, Blažej Palkoci1

  • 11 Surgery Clinic and Transplant Centre, University Hospital Martin and Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.

Progress in Transplantation (Aliso Viejo, Calif.)
|February 7, 2018
PubMed

Insights

Donor obesity and alcohol abuse significantly increase the risk of delayed graft function in kidney transplantation. Identifying these donor factors is crucial for improving transplant outcomes and patient survival.

Area of Science:

  • Nephrology
  • Transplantation Surgery
  • Public Health

Background:

  • Delayed graft function (DGF) is a major complication after kidney transplantation.
  • Identifying modifiable donor factors can optimize organ utilization and improve graft survival.

Purpose of the Study:

  • To investigate donor and recipient parameters associated with the development of DGF.
  • To identify specific risk factors for DGF in kidney transplant recipients.

Main Methods:

  • Retrospective analysis of 152 beating heart donors and 179 kidney transplant recipients over 5 years.
  • Statistical analysis to determine predictors and independent risk factors for DGF.

Main Results:

  • DGF occurred in 17% of recipients.
  • Donor body mass index (BMI) was a significant predictor of DGF.
  • Independent risk factors included donor BMI of 30-34.9 kg/m² (HR: 6.02) and ≥35 kg/m² (HR: 13.55).
  • Donor history of alcohol abuse also increased DGF risk (HR: 1.78).

Conclusions:

  • Donor BMI and a history of alcohol abuse are critical risk factors for DGF.
  • These findings highlight the importance of donor selection criteria in kidney transplantation.
  • Strategies to mitigate DGF risk should consider donor weight and substance use history.

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