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Published on: January 22, 2012
Donor Body Mass Index as a Risk Factor for Delayed Onset of Graft Function
Juraj Miklušica1, Ivana Dedinská1, Blažej Palkoci1
11 Surgery Clinic and Transplant Centre, University Hospital Martin and Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.
Insights
Donor obesity and alcohol abuse significantly increase the risk of delayed graft function in kidney transplantation. Identifying these donor factors is crucial for improving transplant outcomes and patient survival.
Area of Science:
- Nephrology
- Transplantation Surgery
- Public Health
Background:
- Delayed graft function (DGF) is a major complication after kidney transplantation.
- Identifying modifiable donor factors can optimize organ utilization and improve graft survival.
Purpose of the Study:
- To investigate donor and recipient parameters associated with the development of DGF.
- To identify specific risk factors for DGF in kidney transplant recipients.
Main Methods:
- Retrospective analysis of 152 beating heart donors and 179 kidney transplant recipients over 5 years.
- Statistical analysis to determine predictors and independent risk factors for DGF.
Main Results:
- DGF occurred in 17% of recipients.
- Donor body mass index (BMI) was a significant predictor of DGF.
- Independent risk factors included donor BMI of 30-34.9 kg/m² (HR: 6.02) and ≥35 kg/m² (HR: 13.55).
- Donor history of alcohol abuse also increased DGF risk (HR: 1.78).
Conclusions:
- Donor BMI and a history of alcohol abuse are critical risk factors for DGF.
- These findings highlight the importance of donor selection criteria in kidney transplantation.
- Strategies to mitigate DGF risk should consider donor weight and substance use history.
Abstract:
Delayed graft function continues to pose a significant challenge to clinicians in the context of kidney transplantation. The objective of this retrospective, 5-year analysis is to identify the parameters of beating heart donors and those of recipients that affect the delayed development of graft function. The monitored group was composed of 152 beating heart donors and 179 recipients. Delayed graft function was identified in 32 (17%) patients. The predictor for development of delayed graft function was the body mass index of the donor (odds ratio: 1.1473; 95% confidence interval [CI]: 1.0017-1.3140; P = .0472), and the independent risk factors were donor body mass index 30 to 34.9 kg/m2 (hazard ratio [HR]: 6.0215; 95% CI: 1.4188-25.556; P = .0149), donor body mass index ≥35 kg/m2 (HR: 13.5484; 95% CI: 1.4575-125.938; P = .0220), and abuse of alcohol in the donor's history (HR: 1.779; 95% CI: 1.0679-2.964; P = .0270).
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